Endocrine Abstracts

A 43-year-old roman, previously living in France was referred to the endocrinology department for Hashimoto’s hypothyroidism in 2017. Thyroid function was easily normalized by a treatment by thyroxine. She had also a medical history of severe alopecia since the age of 20. The diagnosis of androgenetic alopecia was made at that time by a French dermatologist and treatment by estradiol valerate 2 mg with cyproterone acetate (CPA) 50 mg was started. The dose of CPA was lower...

Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor highly resistant to chemo-and radiotherapy. Since several reports showed that cAMP has an antiproliferative effect on different types of solid tumors both in vitro and in vivo, we evaluated the potential anti-neoplastic activity of cAMP analogues (8-Cl-cAMP and the equimolar combination of 8-PIP-cAMP and 8-HA-cAMP) in two MTC cell lines (TT and MZ-CRC-1 that harbor C634W and M918T RET mutations, respecti...

Treatment of adrenocortical carcinoma (ACC) is still unsatisfactory. As IGF-II and IGF-I receptor are frequently overexpressed in human ACC and inhibitors of the IGF system are currently under preclinical investigation, interference with IGF-signaling might have an additive effect in antitumour treatment. We have therefore analyzed several cytotoxic agents (etoposide, doxorubicine, cisplatin, streptocozin; 0.01–100 μM) on adrenal cell proliferation in vitro an...

Objective: Acoustic radiation force impulse (ARFI)-imaging is a novel ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of the present study was to evaluate the feasibility of ARFI-measurements in the thyroid tissue.Materials and methods: ARFI-imaging involves the mechanical excitation of tissue using short-duration acoustic pulses to generate localized displacements in tissue. The displacements result in...

Oncogenic osteomalacia (tumor induced osteomalacia-TIO) is a rare disease that can lead to severe physical handicap and pains. Its pathogenesis involves the secretion of fibroblast growth factor-23 inducing urinary phosphate loss and consequent hypophosphataemia. We report a case of a TIO caused by a tumor in the nasal cavity. In 2010, a 61-years-old woman was examined because of muscle weakness and arthralgia in the extremities. Her symptomes started ~3 years before her prese...

Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this...

Recently, since the lives of patients with chronic renal failure have prolonged considerably, the importance of prevention and treatment of metabolic bone disease which inevitably develops in this group, has become better appreciated.The aim of this study was to evaluate the relation between bone mineral density (BMD) and specific markers of bone turnover in haemodialysis (HD) population.A cross-sectional study involving 40 HD pati...

Aging is associated with weight loss, appetite decline, reduced fat-free mass (FFM) and increased fat mass (FM). Dysregulation of the ghrelin and leptin systems could reduce hunger and promote early satiety in elderly subjects, leading to impairment of the nutritional status. To better clarify this issue, we evaluated the response of plasma ghrelin and leptin to a standardised oral mixed nutrient load (SOMNL) in elderly subjects with different body composition. The study popul...

Congenital morphological thyroid abnormalities can be classified as hemiagenesis or total agenesis, lingual thyroid, substernal thyroid, thyroglossal ductus remnant. Hemiagenesis with absence of one lobe or lobe and isthmus is very rare, it was found in 4 of 7000 scans in one study. The left lobe is absent four times as often as the right lobe, and women are about three times more likely than men to have this developmental defect. Usually diagnosing this condition is not very ...

Studies in rats suggest that androgens are involved in sex-specific differences in blood pressure. In human studies there is no difference in blood pressure between boys and girls, but following puberty, men present with a higher blood pressure than women. Modulation of sodium reabsorption through the ENaC is an important component in the control of sodium balance. This is clearly demonstrated by rare genetic disorders of sodium-channel activity (Liddle's syndrome and pseudohy...